Lithospermi radix Extract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells

Eun Kyoung KIM; Eun-Young KIM; Phil-Dong MOON; Jae-Young UM; Hyung-Min KIM; Hyun-Sam LEE; Youngjoo SOHN; Seong Kyu PARK; Hyuk-Sang JUNG; Nak-Won SOHN

doi:10.1271/bbb.70208

Food & Nutrition Science Regular Papers

Lithospermi radix Extract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells

Eun Kyoung KIM, Eun-Young KIM, Phil-Dong MOON, Jae-Young UM, Hyung-Min KIM, Hyun-Sam LEE, Youngjoo SOHN, Seong Kyu PARK, Hyuk-Sang JUNG, Nak-Won SOHN

Author information

Eun Kyoung KIM
Department of Anatomy, College of Oriental Medicine, Kyung Hee University
Eun-Young KIM
Department of Anatomy, College of Oriental Medicine, Kyung Hee University
Phil-Dong MOON
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University
Jae-Young UM
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University
Hyung-Min KIM
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University
Hyun-Sam LEE
Department of Anatomy, College of Oriental Medicine, Kyung Hee University
Youngjoo SOHN
Department of Gynecology, College of Oriental Medicine, Sangji University
Seong Kyu PARK
Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University
Hyuk-Sang JUNG
Department of Anatomy, College of Oriental Medicine, Kyung Hee University
Nak-Won SOHN
Department of Anatomy, College of Oriental Medicine, Kyung Hee University

Keywords: Lithospermi radix, HMC-1 cell, passive cutaneous anaphylaxis, cytokine, nuclear factor-kappa B (NF-κB)

JOURNAL FREE ACCESS

2007 Volume 71 Issue 12 Pages 2886-2892

DOI https://doi.org/10.1271/bbb.70208

View "Advance Publication" version (December 7, 2007).

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Abstract

Lithospermi radix (LR, Borraginaceae, the root of Lithospermum erythrorhizon Siebold. et Zuccarinii) is used in herbal medicine to treat such conditions as eczema, skin burns and frostbite. This study investigates the effects of LR on the anti-allergy mechanism. LR inhibited the release of histamine from rat peritoneal mast cells by compound 48/80 in a dose-dependent manner. LR orally administered at 6.59 mg/100 g also inhibited the anti-DNP IgE-induced passive cutaneous anaphylaxis reaction. LR inhibited the PMA plus A23187-induced increase in IL-6, IL-8, and TNF-α expression in HMC-1 cells. In addition, LR also inhibited nuclear factor-kappa B (NF-κB) activation and IκB-α degradation. These results show that LR had an inhibitory effect on the atopic allergic reaction. Furthermore, the in vivo and in vitro anti-allergic effect of LR suggests possible therapeutic applications of this agent for inflammatory allergic diseases.

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