Inhibition of Pathogen Adhesion to Host Cells by Polysaccharides from Panax ginseng

Ji-Hye LEE; Jin Sun SHIM; Mi-Sook CHUNG; Seung-Taik LIM; Kyung Hyun KIM

doi:10.1271/bbb.80555

Microbiology & Fermentation Technology Notes

Inhibition of Pathogen Adhesion to Host Cells by Polysaccharides from Panax ginseng

Ji-Hye LEE, Jin Sun SHIM, Mi-Sook CHUNG, Seung-Taik LIM, Kyung Hyun KIM

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Keywords: polysaccharide, Panax ginseng, anti-adhesion, pathogenic bacteria

JOURNAL FREE ACCESS

2009 Volume 73 Issue 1 Pages 209-212

DOI https://doi.org/10.1271/bbb.80555

View "Advance Publication" version (January 7, 2009).

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Abstract

PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesive properties. PG-F2 and PG-HMW might have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on commensal bacteria.

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