The Activity of a Type II Transmembrane Serine Protease, Matriptase, Is Dependent Solely on the Catalytic Domain

Kenji KOJIMA; Satoshi TSUZUKI; Tohru FUSHIKI; Kuniyo INOUYE

doi:10.1271/bbb.80713

Biochemistry & Molecular Biology Notes

The Activity of a Type II Transmembrane Serine Protease, Matriptase, Is Dependent Solely on the Catalytic Domain

Kenji KOJIMA, Satoshi TSUZUKI, Tohru FUSHIKI, Kuniyo INOUYE

Author information

Keywords: catalytic domain, enzyme activity, matriptase, membrane-type serine protease, stem domain

JOURNAL FREE ACCESS

2009 Volume 73 Issue 2 Pages 454-456

DOI https://doi.org/10.1271/bbb.80713

View "Advance Publication" version (February 7, 2009).

Details

Abstract

Matriptase is a transmembrane serine protease comprising multiple domains in the extracellular region, including a stem domain and a catalytic domain. Using soluble matriptase variants containing entire extracellular domains or only the catalytic domain, the activity of this protease was found to depend solely on the catalytic domain. The stem domain had no significant effect on the activity.

Corresponding author

Register with J-STAGE for free!