Banana Peel Extract Suppressed Prostate Gland Enlargement in Testosterone-Treated Mice

Kiichiro AKAMINE; Tomoyuki KOYAMA; Kazunaga YAZAWA

doi:10.1271/bbb.80770

Food & Nutrition Science Regular Papers

Banana Peel Extract Suppressed Prostate Gland Enlargement in Testosterone-Treated Mice

Kiichiro AKAMINE, Tomoyuki KOYAMA, Kazunaga YAZAWA

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Keywords: suppressive effect on benign prostate hyperplasia, inhibitor of 5alpha-reductase, banana peel extract, anti-androgen effect, mice

JOURNAL FREE ACCESS

2009 Volume 73 Issue 9 Pages 1911-1914

DOI https://doi.org/10.1271/bbb.80770

View "Advance Publication" version (September 7, 2009).

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Abstract

A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-responsive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

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