Effects of Psilocybe argentipes on Marble-Burying Behavior in Mice

Yoshihiro MATSUSHIMA; Osamu SHIROTA; Ruri KIKURA-HANAJIRI; Yukihiro GODA; Fumio EGUCHI

doi:10.1271/bbb.90095

Biochemistry & Molecular Biology Notes

Effects of Psilocybe argentipes on Marble-Burying Behavior in Mice

Yoshihiro MATSUSHIMA, Osamu SHIROTA, Ruri KIKURA-HANAJIRI, Yukihiro GODA, Fumio EGUCHI

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Keywords: Psilocybe argentipes, hallucinogenic mushrooms, psilocybin, marble-burying behavior, obsessive-compulsive disorder

JOURNAL FREE ACCESS

2009 Volume 73 Issue 8 Pages 1866-1868

DOI https://doi.org/10.1271/bbb.90095

View "Advance Publication" version (August 7, 2009).

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Abstract

Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.

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