Endoplasmic Reticulum (ER) Stress-Suppressive Compounds from Scrap Cultivation Beds of the Mushroom Hericium erinaceum

Keiko UEDA; Shinya KODANI; Masakazu KUBO; Kazuhiko MASUNO; Atsushi SEKIYA; Kaoru NAGAI; Hirokazu KAWAGISHI

doi:10.1271/bbb.90279

Organic Chemistry Notes

Endoplasmic Reticulum (ER) Stress-Suppressive Compounds from Scrap Cultivation Beds of the Mushroom Hericium erinaceum

Keiko UEDA, Shinya KODANI, Masakazu KUBO, Kazuhiko MASUNO, Atsushi SEKIYA, Kaoru NAGAI, Hirokazu KAWAGISHI

Author information

Keywords: Hericium erinaceum, mushroom, scrap cultivation bed, structural determination, endoplasmic reticulum stress-suppressive compound

JOURNAL FREE ACCESS

2009 Volume 73 Issue 8 Pages 1908-1910

DOI https://doi.org/10.1271/bbb.90279

View "Advance Publication" version (August 7, 2009).

Details

Abstract

Four compounds were isolated from scrap cultivation beds of the mushroom, Hericium erinaceum. Compounds 1–4 were identified as methyl 4-hydroxy-3-(3-methylbutanoyl) benzoate, 2-chloro-1,3-dimethoxy-5-methylbenzene, methyl 4-chloro-3,5-dimethoxybenzoate, and 4-chloro-3,5-dimethoxybenzaldehyde by an interpretation of the NMR and MS data, respectively. This is the first reported isolation of 1 from a natural source. All the compounds showed protective activity against endoplasmic reticulum stress-dependent cell death.

Corresponding author

Register with J-STAGE for free!