Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
Protective Effects of Cinnamomum cassia Blume in the Fibrogenesis of Activated HSC-T6 Cells and Dimethylnitrosamine-Induced Acute Liver Injury in SD Rats
Chang-Shin LIM, Eun-Young KIM, Hyun-Sam LEE, Yunjo SOH, Youngjoo SOHN, Sun Yeou KIM, Nak-Won SOHN, Hyuk-Sang JUNG, Yoon-Bum KIM
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Keywords: hepatic stellate cell (HSC)-T6, alpha-smooth muscle actin (α-SMA), dimethylnitrosamine, Cinnamomum cassia Blume
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2010 Volume 74 Issue 3 Pages 477-483

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Abstract

Cinnamomum cassia Blume (CC) is one of the world’s oldest natural spices, and is commonly used in traditional oriental medicine. We investigated the protective effect of ethanol extract from Cinnamomum cassia Blume (CCE) on the activation of hepatic stellate cells (HSCs). In addition, we examined the effects of CC powder in Sprague-Dawley rats with acute liver injury induced by dimethylnitrosamine (DMN). In vitro, HSC-T6 cells exhibit an activated phenotype, as reflected in their fibroblast-like morphology. CCE significantly reduced the expression of alpha-smooth muscle actin (α-SMA), connective tissue growth factor (CTGF), transforming growth factor beta (TGF-β1), and tissue inhibitor of metalloproteinase-1 (TIMP-1). In vivo, the results were significantly protected by CC powder in the serum total protein, albumin, total-bilirubin, direct-bilirubin, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and alkaline phosphatase (ALP). We suggest that CC inhibits fibrogenesis, followed by HSC-T6 cell activation and increased restoration of liver function, ultimately resulting in acute liver injury.

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© 2010 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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