Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Analytical Chemistry Regular Paper
Evaluation of the Protective Effects of Chinese Herbs against Biomolecule Damage Induced by Peroxynitrite
Yunjing LUOJinglin PANYanshu PANZhiguo HANRugang ZHONG
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JOURNAL FREE ACCESS

2010 Volume 74 Issue 7 Pages 1350-1354

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Abstract

This work evaluates the protective effects of Chinese herbs against ONOO-induced biomolecule damage. Thirty-two Chinese traditional herbs were preliminarily screened for their ONOO-scavenging activity by the fluorometric method. The potency of scavenging activity was in the following order: Apis cerana Fabricius (Propolis) > Rosmarinus officinalis L (Rosemary) > Pseudolarix amabilis (Nelson) Rehd. (Pine Bark PE) > Echinacea Moenck. (Echinacea); the remaining twenty-eight herbs performed unsatisfactorily for their scavenging activity. The four extracts with high ONOO scavenging activity were selected for further characterization of their inhibiting effects on DNA single breaks, tyrosine nitration and LDL oxidation. A further study of the origin of this scavenging activity on the major active components showed cichoric acid and rosemary acid to both have strong ability to scavenge ONOO. These scavengers might be developed as therapeutic drugs for preventing ONOO-involved diseases.

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© 2010 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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