Hematological Studies on Black Cumin Oil from the Seeds of Nigella sativa L.

Shigeki ENOMOTO; Ryoya ASANO; Yoshihiro IWAHORI; Takao NARUI; Yoshihito OKADA; Abdel Nasser B. SINGAB; Toru OKUYAMA

doi:10.1248/bpb.24.307

Notes

Hematological Studies on Black Cumin Oil from the Seeds of Nigella sativa L.

Shigeki ENOMOTO, Ryoya ASANO, Yoshihiro IWAHORI, Takao NARUI, Yoshihito OKADA, Abdel Nasser B. SINGAB, Toru OKUYAMA

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Keywords: black cumin oil, Nigella sativa, platelet aggregation, 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol, thymol, carvacrol

JOURNAL FREE ACCESS

2001 Volume 24 Issue 3 Pages 307-310

DOI https://doi.org/10.1248/bpb.24.307

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Abstract

The methanol soluble portion of black cumin oil, which is prepared by compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic acid (AA)-induced platelet aggregation and blood coagulation. By bioactive assay of AA-induced platelet aggregation, the methanol soluble part was purified to isolate a new compound 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol (1) and two known compounds, thymol (2), carvacrol (3), having very strong inhibitory activity. Further, we then examined the isolated compounds (1—3) and eight related compounds by the screening test for AA-induced platelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl group had more potent activity than aspirin, which is well known as a remedy for thrombosis.

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