Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Screening of South American Plants against Human Immunodeficiency Virus: Preliminary Fractionation of Aqueous Extract from Baccharis trinervis
Sonsoles Sanchez Palomino, María José Abad, Luis Miguel Bedoya, Javier García, Eduardo Gonzales, Ximena Chiriboga, Paulina Bermejo, José Alcami
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Keywords: South American medicinal plant, antiviral activity, Baccharis trinervis, HIV, AIDS
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2002 Volume 25 Issue 9 Pages 1147-1150

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Abstract

Ethanolic and aqueous extracts of 14 South American medicinal plants were tested for inhibitory activity on human immunodeficiency virus (HIV). Both extracts were relatively non-toxic to human lymphocytic MT-2 cells, but only the aqueous extract of Baccharis trinervis exhibited potent anti-HIV activity in an in vitro MTT assay. To delineate the extract-sensitive phase, some studies of the antiviral properties of the active extract are described in this paper. Based on the results presented here, a separation scheme was devised, which permitted the preliminary fractionation of the extract, with the aim of finding an inhibitor of this virus.

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© 2002 The Pharmaceutical Society of Japan
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