Hypotensive Activity and Toxicology of Constituents from Bombax ceiba Stem Bark

Rubeena Saleem; Syed Iqbal Ahmad; Mohammad Ahmed; Zareen Faizi; Sadia Zikr-ur-Rehman; Muhammad Ali; Shaheen Faizi

doi:10.1248/bpb.26.41

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Hypotensive Activity and Toxicology of Constituents from Bombax ceiba Stem Bark

Rubeena Saleem, Syed Iqbal Ahmad, Mohammad Ahmed, Zareen Faizi, Sadia Zikr-ur-Rehman, Muhammad Ali, Shaheen Faizi

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Keywords: novel benzopyran, Bombax ceiba, hypotensive activity, histopathology

JOURNAL FREE ACCESS

2003 Volume 26 Issue 1 Pages 41-46

DOI https://doi.org/10.1248/bpb.26.41

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Abstract

A novel constituent, shamimicin, 1′′′, 1′′′′′′′-bis-2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,7-dihydroxy-5-O-xylopyranosyloxy-2H-1-benzopyran alongwith lupeol, which possesses potent hypotensive activity has been isolated from Bombax ceiba stem bark. BCBMM—one of the most active hypotensive fractions has revealed its adverse effects on heart, liver and kidneys of mice at the dose of 1000 mg/kg/d.

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