Antioxidant Activity of Jionoside D from Clerodendron trichotomum

Sungwook Chae; Ju Sun Kim; Kyoung Ah Kang; Hyung Deuk Bu; Youngki Lee; Jin Won Hyun; Sam Sik Kang

doi:10.1248/bpb.27.1504

Regular Articles

Antioxidant Activity of Jionoside D from Clerodendron trichotomum

Sungwook Chae, Ju Sun Kim, Kyoung Ah Kang, Hyung Deuk Bu, Youngki Lee, Jin Won Hyun, Sam Sik Kang

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Keywords: antioxidant activity, Clerodendron trichotomum, jionoside D, radical scavenging activity, antioxidant enzyme

JOURNAL FREE ACCESS

2004 Volume 27 Issue 10 Pages 1504-1508

DOI https://doi.org/10.1248/bpb.27.1504

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Abstract

The antioxidant property of jionoside D, isolated from Clerodendron trichotomum (Verbenaceae), was investigated. This compound showed scavenging activity of intracellular reactive oxygen species and of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as lipid peroxidation inhibitory activity. This radical scavenging activity of jionoside D protected the cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed H₂O₂. Furthermore, jionoside D reduced the apoptotic cells induced by H₂O₂, as demonstrated by the decreased number of sub G₁ hypo-diploid cells and apoptotic body formation. However, it increased the activities of cellular antioxidant enzymes, superoxide dismutase and catalase. Taken together, these findings suggest that jionoside D, isolated from C. trichotomum, exhibits antioxidant properties.

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