Farnesol, a Morphogenetic Autoregulatory Substance in the Dimorphic Fungus Candida albicans, Inhibits Hyphae Growth through Suppression of a Mitogen-Activated Protein Kinase Cascade

Tatsuki Sato; Toshihiko Watanabe; Takeshi Mikami; Tatsuji Matsumoto

doi:10.1248/bpb.27.751

Notes

Farnesol, a Morphogenetic Autoregulatory Substance in the Dimorphic Fungus Candida albicans, Inhibits Hyphae Growth through Suppression of a Mitogen-Activated Protein Kinase Cascade

Tatsuki Sato, Toshihiko Watanabe, Takeshi Mikami, Tatsuji Matsumoto

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Keywords: Candida albicans, dimorphism, farnesol, cAMP-EFG1 pathway, mitogen activated protein (MAP) kinase cascade

JOURNAL FREE ACCESS

2004 Volume 27 Issue 5 Pages 751-752

DOI https://doi.org/10.1248/bpb.27.751

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Abstract

Candida albicans grew in hyphal form in RPMI1640, however, addition of farnesol inhibited the formation. Farnesol did not affect the expression of mRNAs related to cAMP-EFG1 pathways. The mRNAs (HST7 and CPH1) in mitogen activated protein kinase (MAP) cascades were decreased in farnesol-treated cells, but CST20 was not. Furthermore, expression of general amino acid permease 1 (GAP1) was decreased by farnesol. We concluded that farnesol inhibits a MAP kinase cascades, and the suppression is a cause of interruption of hyphae formation.

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