Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Hyphae Formation of Candida albicans Is Regulated by Polyamines
Yukihiro UenoMakoto FukumatsuAyako OgasawaraToshihiko WatanabeTakeshi MikamiTatsuzi Matsumoto
Author information
JOURNAL FREE ACCESS

2004 Volume 27 Issue 6 Pages 890-892

Details
Abstract

Candida albicans generally grows in hyphae form in RPMI1640 medium. However, addition of 1,4-diamino-2-butanone (DAB), a competitive inhibitor of ornithine decarboxylase, decreased the amount of polyamines in C. albicans, and induced the proliferation of the C. albicans yeast form. The expression of CYR1 mRNA was significantly inhibited by the addition of DAB compared with that of the control. The amount of intracellular cAMP was also decreased by the addition of DAB. A specific adenylate cyclase inhibitor, cis-N-[2-phenylcyclopentyl]-azacyclotridec-1-en-2-amine (MDL-12,330A) promoted the growth of the yeast form. These results indicated that polyamines exist upstream of the adenylate cyclase-cAMP signal pathway and regulate the transformation of C. albicans.

Content from these authors
© 2004 The Pharmaceutical Society of Japan
Previous article
feedback
Top