Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Analysis and Bioactive Evaluation of the Compounds Absorbed into Blood after Oral Administration of the Extracts of Vaccinium vitis-idaea in Rat
Xijun WangHui SunYuling FanLijing LiToshiaki MakinoYoshihiro Kano
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JOURNAL FREE ACCESS

2005 Volume 28 Issue 6 Pages 1106-1108

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Abstract

In order to screen the active constituents of Vaccinium vitis-idaea L., the compounds absorbed into the rat blood after oral administration of ethanol extract of the stems and leaves of V. vitis-idaea (EEV) have been analyzed. Two compounds were detected in the plasma and identified as arbutin and fraxin, which are originally existed in the crude drug. Furthermore, the pharmacological effects of the two compounds involving EEV for curing acute and chronic respiratory tract infection were tested. The results showed that both arbutin and fraxin have the anti-inflammatory, anti-coughing and phlegm-removing effects. Therefore, it was ascertained that the arbutin and fraxin would be the main active constituents of V. vitis-idaea L.

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© 2005 The Pharmaceutical Society of Japan
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