Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica
Miyako Yoshida, Masahiro Fuchigami, Tsuneatsu Nagao, Hikaru Okabe, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube, Ryota Tsuchihashi, Junei Kinjo, Kunihide Mihashi, Toshihiro Fujioka
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Keywords: Centella asiatica, antiproliferative activity, Umbelliferae, triterpene
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2005 Volume 28 Issue 1 Pages 173-175

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Abstract

The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2α,3α-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated.

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© 2005 The Pharmaceutical Society of Japan
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