Inhibition of Helicobacter pylori Motility by (+)-Syringaresinol from Unripe Japanese Apricot

Mitsuo Miyazawa; Hirotoshi Utsunomiya; Ken-ichi Inada; Tomoki Yamada; Yoshiharu Okuno; Harunari Tanaka; Masae Tatematsu

doi:10.1248/bpb.29.172

Notes

Inhibition of Helicobacter pylori Motility by (+)-Syringaresinol from Unripe Japanese Apricot

Mitsuo Miyazawa, Hirotoshi Utsunomiya, Ken-ichi Inada, Tomoki Yamada, Yoshiharu Okuno, Harunari Tanaka, Masae Tatematsu

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Keywords: Helicobacter pylori, (+)-syringaresinol, Japanese apricot

JOURNAL FREE ACCESS

2006 Volume 29 Issue 1 Pages 172-173

DOI https://doi.org/10.1248/bpb.29.172

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Abstract

A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 μg/ml and the IC₅₀ value was 50 μg/ml.

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