Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Changes in Immune Responses to Mite Antigen Sensitized through Barrier-Disrupted Skin with CpG-Oligodeoxynucleotide in Mice
Joe InoueSatoshi YotsumotoTakatoshi SakamotoSeishi TsuchiyaYukihiko Aramaki
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2006 Volume 29 Issue 2 Pages 385-387

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Abstract

CpG-oligodeoxynucleotide (CpG-ODN) plays a critical role in immunity via the augmentation of Th1 and suppression of Th2 responses. We examined here the effect of CpG-ODN on the immune response to mite antigen sensitized through barrier-disrupted skin of human atopic dermatitis (AD) model mouse. Although sensitization with mite antigen induced Th2-dominant immune response, co-administration of CpG-ODN elicited Th1-predominant immune response. In terms of antigen-specific antibody production, the level of IgG2a was increased by CpG-ODN, but not in IgE. These results suggested that administration of CpG-ODN via skin is a simple strategy for patients with diseases like AD, which is characterized by Th2-dominated inflammation.

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© 2006 The Pharmaceutical Society of Japan
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