Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Ovalicin Ameliorates Compound 48/80-Induced Atopic Dermatitis-Related Symptoms
Cheol-Sik YoonSung-Hee NamJi-Young JeonHei-Sam LeeMyeong-Lyeol LeeHyeong-U SonSang-Han Lee
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2011 Volume 34 Issue 12 Pages 1881-1884

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Abstract

Ovalicin, a secondary metabolite produced by an entomopathogenic fungus Metarhizium anisopliae var. anisopliae, is currently used as an efficient biological control agent against various agricultural insect pests, but not so many biological activities have been investigated. To assess whether ovalicin has potential in ameliorating atopic dermatitis-related symptoms in mice, we first sensitized skin in the dorsal neck of Balb/c mice using compound 48/80, and scrutinized whether the compound affected the atopic dermatitis-related symptoms. The results revealed that ovalicin significantly reduces scratching behavior in a concentration-dependent fashion. Moreover, the treatment inhibits the levels of the degranulation of mast cells by 65%, and levels of histamine release by 51% at a concentration of 10 μg/ml. Together, the present data strongly suggest that ovalicin elicits potential anti-atopic activities in mice.

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© 2011 The Pharmaceutical Society of Japan
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