Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Specific Interaction between Ca2+ and Anionic Lipids in Cancer Cells along with Apoptosis
Koichi GotoKazuki TatsumiToshihiro NagataYuji KomizuRyuichi Ueoka
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2011 Volume 34 Issue 3 Pages 439-442

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Abstract

Markedly inhibitory effects of Ca2+ on the growth of human tumor cells were attained through the induction of apoptosis in vitro. On the other hand, a good correlation between the growth inhibition effects of Ca2+ and the amounts of phosphatidylserines (PS) in the cell membranes (plasma membranes) was obtained. Furthermore, the decrease of membrane fluidity and the localization of lipid microdomains “lipid rafts” in the cell membranes were observed in the presence of Ca2+. The findings in this study suggest that Ca2+ could induce apoptosis toward tumor cells through the localization of lipid rafts in plasma membranes by the specific interactions between extracellular Ca2+ and PS.

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© 2011 The Pharmaceutical Society of Japan
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