Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
High-Frequency Genetic Contents Variations in Clinical Candida albicans Isolates
Feng Yang, Tian-Hua Yan, Elena Rustchenko, Ping-Hui Gao, Yan Wang, Lan Yan, Ying-Ying Cao, Qiu-Juan Wang, Hui Ji, Yong-Bing Cao, Yuan-Ying Jiang
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Keywords: Candida albicans, comparative genomic, copy number variation, array-based comparative genomic hybridization
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2011 Volume 34 Issue 5 Pages 624-631

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Abstract

Genome plasticity is a hallmark of Candida albicans and is believed to be an adaptation strategy. But the extent of such genomic variability is not well investigated. In this study, genetic contents of clinical C. albicans isolates were investigated at whole-genome level with array-based comparative genomic hybridization (array CGH) technology. It was revealed that C. albicans possessed variations of genetic contents, as well as aneuploidy. The variable genes were scattered across the chromosomes, as well clustered in particular regions, including sub-telomeric regions, retrotransposon-insertion sites and a variable region on chromosome 6.

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© 2011 The Pharmaceutical Society of Japan
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