Effect of Intravenous Propranolol on Left Ventricular Apical Ballooning Without Coronary Artery Stenosis (Ampulla Cardiomyopathy) Three Cases

Michifumi Kyuma; Kazufumi Tsuchihashi; Yasuyuki Shinshi; Mamoru Hase; Tomoaki Nakata; Hitoshi Ooiwa; Masayoshi Abiru; Nobuichi Hikita; Tateo Adachi; Tetsuro Shoji; Yukiyasu Fujise; Kazuaki Shimamoto

doi:10.1253/circj.66.1181

Case Report

Effect of Intravenous Propranolol on Left Ventricular Apical Ballooning Without Coronary Artery Stenosis (Ampulla Cardiomyopathy)

Three Cases

Michifumi Kyuma, Kazufumi Tsuchihashi, Yasuyuki Shinshi, Mamoru Hase, Tomoaki Nakata, Hitoshi Ooiwa, Masayoshi Abiru, Nobuichi Hikita, Tateo Adachi, Tetsuro Shoji, Yukiyasu Fujise, Kazuaki Shimamoto

Author information

Michifumi Kyuma
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
Kazufumi Tsuchihashi
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
Yasuyuki Shinshi
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
Mamoru Hase
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
Tomoaki Nakata
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
Hitoshi Ooiwa
Division of Cardiovascular Medicine, Oji General Hospital, Tomakomai
Masayoshi Abiru
Division of Cardiovascular Medicine, Oji General Hospital, Tomakomai
Nobuichi Hikita
Division of Cardiovascular Medicine, Muroran City General Hospital, Muroran
Tateo Adachi
Division of Cardiovascular Medicine, Muroran City General Hospital, Muroran
Tetsuro Shoji
Division of Cardiovascular Medicine, Muroran City General Hospital, Muroran
Yukiyasu Fujise
Division of Cardiovascular Medicine, Oji General Hospital, Tomakomai
Kazuaki Shimamoto
Second Department of Internal Medicine, Sapporo Medical University School of Medicine

Keywords: Ampulla cardiomyopathy, Propranolol, Regional apical ballooning, Takotsubo cardiomyopathy

JOURNAL FREE ACCESS

2002 Volume 66 Issue 12 Pages 1181-1184

DOI https://doi.org/10.1253/circj.66.1181

Details

Abstract

The precise etiological basis of transient left ventricular apical ballooning without coronary artery stenosis (ampulla or so-called `takotsubo' cardiomyopathy) remains unknown, so the present study examined the acute effects of intravenous propranolol (2-4 mg) in 3 female patients (age range, 61-76 years) with the condition. Although one patient who did not have any intraventricular pressure gradients showed no improvement in the electrocardiographic and left ventricular wall motion abnormalities, the other 2 patients, who had significant intraventricular pressure gradients, did show improvement. Dynamic intraventricular obstruction might play a role in maintaining apical ballooning, at least, in patients exhibiting an intraventricular pressure gradient. (Circ J 2002; 66: 1181 - 1184)

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