Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Experimental Investigation
Digital Radiographic Quantification of Myocardial Blood Flow Around a Transmyocardial Laser Channel in Rabbit Hearts
Osami HonjoKozo IshinoTakeshi MatsumotoShu YamamotoTomohiro AsaiTakushi KohmotoFumihiko KajiyaShunji Sano
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2005 Volume 69 Issue 4 Pages 488-492

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Abstract

Background A mechanism underlying the benefits of transmyocardial laser revascularization (TMLR) has been presumed to be improvement in perfusion. We evaluated myocardial blood flow around a laser channel using digital radiography combined with a 3H-labeled desmethylimipramine ([3H]DMI) deposition. Methods and Results A laser channel was created in the left ventricular wall using a YAG-laser in 6 non-ischemic rabbit hearts. After 8 weeks, [3H]DMI(1.11 MBq) was injected into the left atrium and the TMLR-treated myocardium was sectioned. Another 6 hearts were examined as controls. We measured [3H]DMI density in arbitrary units with digital radiography in the channel remnant, the surrounding area and a remote area. Flow distribution was quantified by the coefficient of variation of flows (CV). The surrounding area had the highest density (p<0.001) and the lowest CV (p<0.001), and had higher density (p<0.001) and lower CV (p<0.001) than the controls. There was no transmural difference in the density in all domains. The CV increased with depth in the remote area, as well as in controls (p<0.001), but there was no transmural difference in the surrounding area. Conclusions The TMLR increases myocardial blood flow and decreases flow heterogeneity in the surrounding area. The disappearance of transmural difference in flow heterogeneity might indicate the remodeling of microcirculation to improve regional oxygen delivery. (Circ J 2005; 69: 488 - 492)

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© 2005 THE JAPANESE CIRCULATION SOCIETY
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