Altered Interaction Between Plasminogen Activator Inhibitor Type 1 Activity and Sympathetic Nerve Activity With Aging

Kan-ichi Otowa; Masayuki Takamura; Hisayoshi Murai; Michirou Maruyama; Manabu Nakano; Tatsunori Ikeda; Daisuke Kobayashi; Hiroshi Ootsuji; Masaki Okajima; Hiroshi Furushou; Toyoshi Yuasa; Shigeo Takata; Shuichi Kaneko

doi:10.1253/circj.72.458

Clinical Investigation

Altered Interaction Between Plasminogen Activator Inhibitor Type 1 Activity and Sympathetic Nerve Activity With Aging

Kan-ichi Otowa, Masayuki Takamura, Hisayoshi Murai, Michirou Maruyama, Manabu Nakano, Tatsunori Ikeda, Daisuke Kobayashi, Hiroshi Ootsuji, Masaki Okajima, Hiroshi Furushou, Toyoshi Yuasa, Shigeo Takata, Shuichi Kaneko

Author information

Kan-ichi Otowa
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Masayuki Takamura
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Hisayoshi Murai
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Michirou Maruyama
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Manabu Nakano
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Tatsunori Ikeda
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Daisuke Kobayashi
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Hiroshi Ootsuji
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Masaki Okajima
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Hiroshi Furushou
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Toyoshi Yuasa
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
Shigeo Takata
Department of Cardiology, Kanazawa City Hospital
Shuichi Kaneko
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University

Keywords: Fibrinolysis, Lower body negative pressure, Muscle sympathetic nerve activity, Plasminogen activator inhibitor type 1

JOURNAL FREE ACCESS

2008 Volume 72 Issue 3 Pages 458-462

DOI https://doi.org/10.1253/circj.72.458

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Abstract

Background It has been reported that sympathetic nerve activity (SNA) is associated with fibrinolysis, but the interaction between SNA and the fibrinolytic system with aging has not been elucidated in humans. The purpose of this study was to examine the effect of age-related SNA on the activity of plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (tPA) using muscle SNA (MSNA). Methods and Results This study included 16 young subjects (mean age 26.1 years) and 10 aged subjects (mean age 56.9 years). Lower body negative pressure (LBNP) was performed at -40 mmHg for 30 min. LBNP significantly increased both tPA and PAI-1 activity (from 5.2±0.5 to 7.3±1.2 IU/ml and from 2.85±0.68 to 4.06±0.73 U/ml, p<0.01, respectively) in the aged group. In the young group, tPA activity tended to increase, whereas PAI-1 activity was unchanged. There was a correlation between MSNA and PAI-1 activity in the aged group (r=0.47, p<0.01). Conclusions SNA in an aging subject leads to an increase in the activity of PAI-1, which indicates that an altered interaction between SNA and PAI-1 activity contributes to increased cardiovascular events in the elderly population. (Circ J 2008; 72: 458 - 462)

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