Rationale and Design of the Carotid Plaque in Human for All Evaluations With Aggressive Rosuvastatin Therapy (CHALLENGER Trial) Evaluation by Magnetic Resonance Imaging

Katsumi Miyauchi; Norihide Takaya; Takahisa Hirose; Fuki Ikeda; Ryuzo Kawamori; Hidenori Ohishi; Kensaku Yoshida; Munetaka Yamamoto; Hajime Arai; Takao Urabe; Nobutaka Hattori; Michimasa Suzuki; Tadayuki Maehara; Kazuhiro Sase; Thomas S. Hatsukami; Chun Yuan; Hiroyuki Daida

doi:10.1253/circj.CJ-08-0135

Imaging

Rationale and Design of the Carotid Plaque in Human for All Evaluations With Aggressive Rosuvastatin Therapy (CHALLENGER Trial)

Evaluation by Magnetic Resonance Imaging

Katsumi Miyauchi, Norihide Takaya, Takahisa Hirose, Fuki Ikeda, Ryuzo Kawamori, Hidenori Ohishi, Kensaku Yoshida, Munetaka Yamamoto, Hajime Arai, Takao Urabe, Nobutaka Hattori, Michimasa Suzuki, Tadayuki Maehara, Kazuhiro Sase, Thomas S. Hatsukami, Chun Yuan, Hiroyuki Daida

Author information

Katsumi Miyauchi
Department of Cardiovascular Medicine, Juntendo University School of Medicine
Norihide Takaya
Department of Cardiovascular Medicine, Juntendo University School of Medicine
Takahisa Hirose
Department of Medicine, Metabolism & Endocrinology, Juntendo University School of Medicine
Fuki Ikeda
Department of Medicine, Metabolism & Endocrinology, Juntendo University School of Medicine
Ryuzo Kawamori
Department of Medicine, Metabolism & Endocrinology, Juntendo University School of Medicine
Hidenori Ohishi
Department of Neurosurgery, Juntendo University School of Medicine
Kensaku Yoshida
Department of Neurosurgery, Juntendo University School of Medicine
Munetaka Yamamoto
Department of Neurosurgery, Juntendo University School of Medicine
Hajime Arai
Department of Neurosurgery, Juntendo University School of Medicine
Takao Urabe
Department of Neurology, Juntendo University School of Medicine
Nobutaka Hattori
Department of Neurology, Juntendo University School of Medicine
Michimasa Suzuki
Department of Radiology, Juntendo University School of Medicine
Tadayuki Maehara
Department of Radiology, Juntendo University School of Medicine
Kazuhiro Sase
Department of Clinical Phamacology, Juntendo University School of Medicine
Thomas S. Hatsukami
Department of Surgery, University of Washington, Seattle
VA Puget Sound Health Care System
Chun Yuan
Department of Radiology, University of Washington, Seattle
Hiroyuki Daida
Department of Cardiovascular Medicine, Juntendo University School of Medicine

Keywords: Carotid intima-media thickness, Carotid plaque, High-resolution magnetic resonance imaging, Plaque stability, Rosuvastatin

JOURNAL FREE ACCESS

2009 Volume 73 Issue 1 Pages 111-115

DOI https://doi.org/10.1253/circj.CJ-08-0135

View "Advance Publication" version (December 4, 2008).

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Abstract

Background Intensive lipid-lowering therapy with statins reduces levels of low-density lipoprotein (LDL)-cholesterol (C) and improves plaque volume and composition in patients with cardiovascular disease. Furthermore, rosuvastatin ameliorated carotid stenosis in the ASTEROID study, and altered the composition of plaques in a predominantly Caucasian study population in the ORION study. However, it is not known whether statin therapy achieves similar quantitative improvement in carotid artery plaque in other ethnic groups. Methods and Results Fifty patients with hypercholesterolemia (LDL-C ≥120 mg/dl) and a maximum carotid intima-media thickness ≥1.8 mm will be enrolled and treated with rosuvastatin at a dose of 5 mg/day for 96 weeks. The primary endpoints will be the percent change of carotid plaque volume and the change in plaque composition after 96 weeks of treatment, as evaluated by magnetic resonance imaging. Conclusions The CHALLENGER study will provide a noninvasive assessment of the changes in carotid plaque volume and composition achieved by reduction of LDL levels in Japanese patients with carotid stenosis on long-term rosuvastatin therapy. (Circ J 2009; 73: 111 - 115)

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