Impaired Mobilization of CD133+ Bone Marrow-Derived Circulating Progenitor Cells With an Increased Number of Diseased Coronary Arteries in Ischemic Heart Disease Patients With Diabetes

R. Goekmen Turan; C. Hakan Turan; Ilkay Bozdag-Turan; Jasmin Ortak; Ibrahim Akin; Stephan Kische; Henrik Schneider; Tilo Kleinfeldt; Tim C. Rehders; Mathias Rauchhaus; Esther Adolph; Shwan Amen; Tina Hermann; Sedat Yokus; Micheal Brehm; Stephan Steiner; Kurtulus Sahin; Christoph A. Nienaber; Hueseyin Ince

doi:10.1253/circj.CJ-10-1284

Ischemic Heart Disease

Impaired Mobilization of CD133⁺ Bone Marrow-Derived Circulating Progenitor Cells With an Increased Number of Diseased Coronary Arteries in Ischemic Heart Disease Patients With Diabetes

R. Goekmen Turan, C. Hakan Turan, Ilkay Bozdag-Turan, Jasmin Ortak, Ibrahim Akin, Stephan Kische, Henrik Schneider, Tilo Kleinfeldt, Tim C. Rehders, Mathias Rauchhaus, Esther Adolph, Shwan Amen, Tina Hermann, Sedat Yokus, Micheal Brehm, Stephan Steiner, Kurtulus Sahin, Christoph A. Nienaber, Hueseyin Ince

Author information

R. Goekmen Turan
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
C. Hakan Turan
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Ilkay Bozdag-Turan
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Jasmin Ortak
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Ibrahim Akin
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Stephan Kische
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Henrik Schneider
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Tilo Kleinfeldt
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Tim C. Rehders
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Mathias Rauchhaus
Applied Cachexia Research, Department of Cardiology Campus Virchow-Klinikum, Charité-Universitätsmedizin
Esther Adolph
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Shwan Amen
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Tina Hermann
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Sedat Yokus
Laboratory of Stem Cell Transplantation and Molecular Cardiology, Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich-Heine-University
Micheal Brehm
Laboratory of Stem Cell Transplantation and Molecular Cardiology, Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich-Heine-University
Stephan Steiner
Laboratory of Stem Cell Transplantation and Molecular Cardiology, Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich-Heine-University
Kurtulus Sahin
Institute for Clinical Research and Statistics
Christoph A. Nienaber
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock
Hueseyin Ince
Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

Keywords: CD133/45⁺, Diabetes, Ischemic heart disease, Mobilization

JOURNAL FREE ACCESS

2011 Volume 75 Issue 11 Pages 2635-2641

DOI https://doi.org/10.1253/circj.CJ-10-1284

View "Advance Publication" version (August 9, 2011).

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Abstract

Background: The influence of the number of diseased coronary arteries on the mobilization of CD133/45⁺ bone marrow-derived circulating progenitor cells (BM-CPCs) in peripheral blood (PB) in patients with ischemic heart disease (IHD) was analyzed. Methods and Results: Mobilization of CD133/45⁺ BM-CPCs by flow cytometry was measured in 120 patients with coronary 1 vessel (IHD1, n=40), coronary 2 vessel (IHD2, n=40), and coronary 3 vessel disease (IHD3, n=40), and in a control group (n=40). The mobilization of CD133/45⁺ BM-CPCs was significantly reduced in patients with IHD compared to the control group (P<0.001). The mobilization of CD133/45⁺ BM-CPCs was impaired in patients with IHD3 compared to IHD1 (P<0.001) and to IHD2 (P<0.001). But there was no significant difference in mobilization of CD133/45⁺ BM-CPCs between the patients with IHD2 and IHD1 (P=0.35). Moreover, we found significantly reduced CD133/45⁺ cell mobilization in patients with a high SYNTAX-Score (SS) compared to a low SS (P<0.001) and an intermediate SS (P<0.001). In subgroup analyzes, we observed a significantly negative correlation between levels of hemoglobin A_1c and the mobilization of CD133/45⁺ BM-CPCs (P=0.001, r=-0.6). Conclusions: The mobilization of CD133/45⁺ BM-CPCs in PB is impaired in patients with IHD. This impairment might augment with increased number of diseased coronary arteries. Moreover, mobilization of CD133/45⁺ BM-CPCs in ischemic tissue is further impaired by diabetes in patients with IHD. (Circ J 2011; 75: 2635-2641)

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