Pathophysiological Roles of NADPH Oxidase/Nox Family Proteins in the Vascular System – Review and Perspective –

Tetsuro Ago; Junya Kuroda; Masahiro Kamouchi; Junichi Sadoshima; Takanari Kitazono

doi:10.1253/circj.CJ-11-0388

Reviews

Pathophysiological Roles of NADPH Oxidase/Nox Family Proteins in the Vascular System

– Review and Perspective –

Tetsuro Ago, Junya Kuroda, Masahiro Kamouchi, Junichi Sadoshima, Takanari Kitazono

Author information

Keywords: NADPH oxidase/Nox, Reactive oxygen species, Vascular diseases

JOURNAL FREE ACCESS

2011 Volume 75 Issue 8 Pages 1791-1800

DOI https://doi.org/10.1253/circj.CJ-11-0388

View "Advance Publication" version (June 15, 2011).

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Abstract

It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system. (Circ J 2011; 75: 1791-1800)

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