Influence of Achieved Low-Density Lipoprotein Cholesterol Level With Atorvastatin Therapy on Stabilization of Coronary Plaques – Sub-Analysis of the TWINS Study –

Katsuki Okada; Yasunori Ueda; Tadateru Takayama; Junko Honye; Sei Komatsu; Osamu Yamaguchi; Yuxin Li; Junji Yajima; Kenji Takazawa; Shinsuke Nanto; Satoshi Saito; Atsushi Hirayama; Kazuhisa Kodama

doi:10.1253/circj.CJ-11-0966

Ischemic Heart Disease

Influence of Achieved Low-Density Lipoprotein Cholesterol Level With Atorvastatin Therapy on Stabilization of Coronary Plaques

– Sub-Analysis of the TWINS Study –

Katsuki Okada, Yasunori Ueda, Tadateru Takayama, Junko Honye, Sei Komatsu, Osamu Yamaguchi, Yuxin Li, Junji Yajima, Kenji Takazawa, Shinsuke Nanto, Satoshi Saito, Atsushi Hirayama, Kazuhisa Kodama

Author information

Katsuki Okada
Cardiovascular Division, Osaka Police Hospital
Yasunori Ueda
Cardiovascular Division, Osaka Police Hospital
Tadateru Takayama
Division of Cardiology, Department of Medicine, Nihon University, School of Medicine
Junko Honye
Department of Cardiology, Fuchu Keijin-kai Hospital
Sei Komatsu
Cardiovascular Division, Amagasaki Central Hospital
Osamu Yamaguchi
Department of Cardiovascular Medicine, Osaka University, Graduate School of Medicine
Yuxin Li
Department of Advanced Cardiovascular Imaging, Nihon University School of Medicine
Junji Yajima
Department of Cardiology, The Cardiovascular Institute Hospital
Kenji Takazawa
Department of Cardiology, Tokyo Medical University Hachioji Medical Center
Shinsuke Nanto
Department of Advanced Cardiovascular Therapeutics, Osaka University, Graduate School of Medicine
Satoshi Saito
Division of Cardiology, Department of Medicine, Nihon University, School of Medicine
Atsushi Hirayama
Division of Cardiology, Department of Medicine, Nihon University, School of Medicine
Kazuhisa Kodama
Cardiovascular Division, Amagasaki Central Hospital

Keywords: Angioscopy, Atorvastatin, Stabilization of coronary plaque, Yellow plaque

JOURNAL FREE ACCESS

2012 Volume 76 Issue 5 Pages 1197-1202

DOI https://doi.org/10.1253/circj.CJ-11-0966

View "Advance Publication" version (February 17, 2012).

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Abstract

Background: Previously the stabilization of coronary plaque with atorvastatin was demonstrated in the TWINS (evaluaTion With simultaneous angIoscopy and iNtravascular ultraSound) study. The influence of the low-density lipoprotein cholesterol (LDL-C) level on plaque stabilization was analyzed. Methods and Results: Patients (n=29) with hypercholesterolemia and coronary artery disease (CAD) were analyzed. They received atorvastatin (10-20mg/day) for 80 weeks and were divided into low (<91mg/dl) and high (≥91mg/dl) LDL-C groups based on their 80-week LDL-C level. Angioscopy was performed before and after treatment. Yellow coronary plaques were classified into six grades (grades 0 to 5) and mean grade was determined for each patient. The LDL-C levels at week 28 and 80 were reduced in both low LDL-C groups (n=14, 140.3 to 77.9 and 75.9mg/dl; P<0.001 both groups) and high LDL-C groups (n=15, 151.7 to 93.0 and 99.1mg/dl; P<0.001 both groups). Significant improvement in the mean grade was shown in the low LDL-C groups (1.44 to 1.00 and 1.05; P=0.003 both groups) at week 28 and 80 vs. no significant change in high LDL-C groups (1.43 to 1.23 and 1.28; P=0.032 and P=0.169 respectively). Conclusions: Adequate reduction of LDL-C is important for the stabilization of coronary plaques. (Circ J 2012; 76: 1197-1202)

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