臨床神経学
Online ISSN : 1882-0654
Print ISSN : 0009-918X
ISSN-L : 0009-918X
シンポジウム8:パーキンソン病の臨床,基礎の最前線
シンポジウム8―2 パーキンソン病の臨床,基礎の最前線 パーキンソン病の病理:レビー小体は悪玉か善玉か?
若林 孝一
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ジャーナル フリー

2008 年 48 巻 11 号 p. 981-983

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The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal degeneration, because neuronal loss is found in the predilection sites for LBs. To date, more than 70 molecules have been identified in LBs, in which α-synuclein is a major constituent of LB fibrils. α-Synuclein immunohistochemistry reveals that diffuse cytoplasmic staining develops into pale bodies via compaction, and that LBs arise from the peripheral portion of pale bodies. Abnormal accumulation of α-synuclein (diffuse cytoplasmic staining, pale bodies and LBs) is found in 10% of pigmented neurons in the substantia nigra and more than 50% of those in the locus ceruleus in PD. Recent studies have suggested that oligomers and protofibrils of α-synuclein are cytotoxic, and that pale bodies and LBs may represent a cytoprotective mechanism in PD.

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© 2008 日本神経学会
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