Analgesic Components of Saposhnikovia Root (Saposhnikovia divaricata)

Emi OKUYAMA; Tetsuya HASEGAWA; Takamitsu MATSUSHITA; Haruhiro FUJIMOTO; Masami ISHIBASHI; Mikio YAMAZAKI

doi:10.1248/cpb.49.154

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Analgesic Components of Saposhnikovia Root (Saposhnikovia divaricata)

Emi OKUYAMA, Tetsuya HASEGAWA, Takamitsu MATSUSHITA, Haruhiro FUJIMOTO, Masami ISHIBASHI, Mikio YAMAZAKI

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Keywords: Saposhnikovia divaricata, analgesia, divaricatol, (3'S)-hydroxydeltoin, chromone, 1-acylglycerol

JOURNAL FREE ACCESS

2001 Volume 49 Issue 2 Pages 154-160

DOI https://doi.org/10.1248/cpb.49.154

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Abstract

By activity-oriented separation using the writhing method in mice, the analgesic components of Saposhnikovia root (Saposhnikovia divaricata Schischkin; Umbelliferae) were identified to be chromones, coumarins, polyacetylenes and 1-acylglycerols. Two new components, divaricatol and (3'S)-hydroxydeltoin, were also isolated. The most potent analgesia was observed in chromones such as divaricatol, ledebouriellol and hamaudol, which inhibited writhing inhibition at an oral dose of 1 mg/kg in mice. Acylglycerols also showed inhibition significantly at a dose of 5 mg/kg. In some pharmacological tests using sec-O-glucosylhamaudol, the compound showed analgesia by the tail pressure and the Randall & Selitto methods, and its writhing inhibition was not reversed by naloxone.

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