New Paeonilactone-A Adducts Formed by Anaerobic Incubation of Paeoniflorin with Lactobacillus brevis in the Presence of Arylthiols

Atef A. ABDEL-HAFEZ; Meselhy R. MESELHY; Norio NAKAMURA; Masao HATTORI; Mahmoud A. EL-GENDY; Nadia M. MAHFOUZ; Tarek A. MOHAMED

doi:10.1248/cpb.49.918

Notes

New Paeonilactone-A Adducts Formed by Anaerobic Incubation of Paeoniflorin with Lactobacillus brevis in the Presence of Arylthiols

Atef A. ABDEL-HAFEZ, Meselhy R. MESELHY, Norio NAKAMURA, Masao HATTORI, Mahmoud A. EL-GENDY, Nadia M. MAHFOUZ, Tarek A. MOHAMED

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Keywords: paeonilactone-A, paeoniflorin, intestinal bacteria, Lactobacillus brevis

JOURNAL FREE ACCESS

2001 Volume 49 Issue 7 Pages 918-920

DOI https://doi.org/10.1248/cpb.49.918

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Abstract

During the course of preparing anticonvulsant paeonimetabolin-I adducts, new paeonilactone-A adducts: 9-phenylthiopaeonilactone-A, 9-(o-tolylthio)paeonilactone-A, 9-(m-tolylthio)paeonilactone-A. 9-(p-tolylthio)-paeonilactone-A and 9-(2-naphthylthio)paeonilactone-A, were obtained along with expected paeonimetabolin-I adducts by anaerobic incubation of paeoniflorin from peony roots with Lactobacillus brevis in the presence of the aromatic thiols, phenylthiol, o-tolylthiol, m-tolylthiol, p-tolylthiol and 2-naphthylthiol. The structures of these compounds were determined by spectroscopic methods including two dimensional (2D) NMR.

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