Two Novel Sesquiterpene Lactones, Cytotoxic Vernolide-A and -B, from Vernonia cinerea

Yao-Haur Kuo; Yu-Jen Kuo; Ang-Su Yu; Ming-Der Wu; Chi-Wi Ong; Li-Ming Yang Kuo; Jo-Ti Huang; Chieh-Fu Chen; Shyh-Yuan Li

doi:10.1248/cpb.51.425

Notes

Two Novel Sesquiterpene Lactones, Cytotoxic Vernolide-A and -B, from Vernonia cinerea

Yao-Haur Kuo, Yu-Jen Kuo, Ang-Su Yu, Ming-Der Wu, Chi-Wi Ong, Li-Ming Yang Kuo, Jo-Ti Huang, Chieh-Fu Chen, Shyh-Yuan Li

Author information

Yao-Haur Kuo
National Research Institute of Chinese Medicine, R.O.C.
Department of Chemistry, Chinese Culture University, R.O.C.
Yu-Jen Kuo
Department of Chemistry, Chinese Culture University, R.O.C.
Ang-Su Yu
Department of Chemistry, Chinese Culture University, R.O.C.
Ming-Der Wu
Institute of Chemistry, National Sun Yat-Sen University, R.O.C.
Chi-Wi Ong
Institute of Chemistry, National Sun Yat-Sen University, R.O.C.
Li-Ming Yang Kuo
National Research Institute of Chinese Medicine, R.O.C.
Jo-Ti Huang
National Research Institute of Chinese Medicine, R.O.C.
Chieh-Fu Chen
National Research Institute of Chinese Medicine, R.O.C.
Shyh-Yuan Li
Department of Chemistry, Chinese Culture University, R.O.C.

Keywords: Vernonia cinerea, vernolide-A, vernonia-B, cytotoxicity

JOURNAL FREE ACCESS

2003 Volume 51 Issue 4 Pages 425-426

DOI https://doi.org/10.1248/cpb.51.425

Details

Abstract

Bioassay-directed fractionation of an ethanolic extract of stems of Vernonia cinerea has resulted in the isolation of two novel sesquiterpene lactones, vernolide-A and -B. Their structures were elucidated on the basis of spectroscopic analysis. Biological evaluation showed that vernolide-A demonstrated potent cytotoxicity against human KB, DLD-1, NCI-661, and Hela tumor cell lines (ED₅₀=0.02, 0.05, 0.53, 0.04 μg/ml for KB, DLD-1, NCI-661, and Hela, respectively); vernolide-B had marginal cytoxicity (ED₅₀=3.78, 5.88, 6.42 μg/ml for KB, NCI-661, and Hela, respectively).

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