Cholinesterase Inhibiting Withanolides from Withania somnifera

Muhammad Iqbal Choudhary; Sammer Yousuf; Sarfraz Ahmad Nawaz; Shakil Ahmed; Atta-ur-Rahman

doi:10.1248/cpb.52.1358

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Cholinesterase Inhibiting Withanolides from Withania somnifera

Muhammad Iqbal Choudhary, Sammer Yousuf, Sarfraz Ahmad Nawaz, Shakil Ahmed, Atta-ur-Rahman

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Keywords: Withania somnifera, Solanaceae, withanolide, withaferin A, acetylcholinesterase inhibition, butyrylcholinesterase inhibition

JOURNAL FREE ACCESS

2004 Volume 52 Issue 11 Pages 1358-1361

DOI https://doi.org/10.1248/cpb.52.1358

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Abstract

A total of two new (1, 2) and four known (3—6) withanolides were isolated from the whole plant of Withania somnifera. Their structures were elucidated on the basis of spectroscopic techniques and were characterized as 6α,7α-epoxy-3β,5α,20β-trihydroxy-1-oxowitha-24-enolide (1), 5β,6β-epoxy-4β,17α,27-trihydroxy-1-oxowitha-2,24-dienolide (2), withaferin-A (3), 2,3-dihydrowithaferin-A (4), 6α,7α-epoxy-5α,20β-dihydroxy-1-oxowitha-2,24-dienolide (5), and 5β,6β-epoxy-4β-hydroxy-1-oxowitha-2,14,24-trienolide (6), respectively. Compounds 2, 3, 5, and 6 displayed inhibitory potential against butyrylcholinesterase, but only compounds 3, 4, and 6 were found to be active against acetylcholinesterase.

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