3-Epicabraleahydroxylactone and Other Triterpenoids from Camellia Oil and Their Inhibitory Effects on Epstein–Barr Virus Activation

Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Toshie Suzuki; Fumio Enjo; Kazuo Koike; Tamotsu Nikaido; Hoyoku Nishino

doi:10.1248/cpb.52.153

Notes

3-Epicabraleahydroxylactone and Other Triterpenoids from Camellia Oil and Their Inhibitory Effects on Epstein–Barr Virus Activation

Toshihiro Akihisa, Harukuni Tokuda, Motohiko Ukiya, Toshie Suzuki, Fumio Enjo, Kazuo Koike, Tamotsu Nikaido, Hoyoku Nishino

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Keywords: Camellia japonica, 3-epicabraleahydroxylactone, antitumor promoter, triterpenoids, Epstein–Barr virus early antigen

JOURNAL FREE ACCESS

2004 Volume 52 Issue 1 Pages 153-156

DOI https://doi.org/10.1248/cpb.52.153

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Abstract

The structure of a triterpenoid isolated from the nonsaponifiable lipid (NSL) of the seed oil of the camellia (Camellia japonica L.; Theaceae) was established to be (20S)-3β-hydroxy-25,26,27-trisnordammaran-24,20-olide (1; 3-epicabraleahydroxylactone) on the basis of spectroscopic and chemical methods. Six other triterpenoids isolated from the NSL were identified as 3-epicabraleadiol (2), ocotillol II (3), ocotillol I (4), dammarenediol II (5), (20R)-taraxastane-3β,20-diol (6), and lupane-3β,20-diol (7). Upon evaluation of the seven triterpenoids (1—7) with respect to their inhibitory effects on the induction of Epstein–Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, three compounds (5—7) showed potent inhibitory effects against EBV-EA induction (IC₅₀ values of 277—420 mol ratio/32 pmol TPA).

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