Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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A New and Known Cytotoxic Aryltetralin-Type Lignans from Stems of Bursera graveolens
Tsutomu Nakanishi, Yuka Inatomi, Hiroko Murata, Kaori Shigeta, Naoki Iida, Akira Inada, Jin Murata, Miguel Angel Perez Farrera, Munekazu Iinuma, Toshiyuki Tanaka, Shogo Tajima, Naoto Oku
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Keywords: Bursera graveolens, 4α-aryltetralin-type lignan, burseranin, picropolygamain, cytotoxic activity, Burseraceae
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2005 Volume 53 Issue 2 Pages 229-231

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Abstract

A new 4α-aryltetralin-type lignan called burseranin (1) and a known analogous lignan picropolygamain (2) were isolated along with known triterpenes, lupeol and epi-lupeol from the methanol extract of stems of Bursera graveolens, which showed a remarkable inhibitory activity against human HT1080 fibrosarcoma cells. The whole structure of 1 was established based on combined spectral studies and the absolute structure for 2 was first confirmed by CD spectral evidence. In addition, cytotoxic activities of the stem (methanol) extract and its components are evaluated in this paper.

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© 2005 The Pharmaceutical Society of Japan
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