Constituents from the Stems of Hibiscus taiwanensis

Pei-Lin Wu; Tian-Shung Wu; Cai-Xia He; Chia-Hao Su; Kuo-Hsiung Lee

doi:10.1248/cpb.53.56

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Constituents from the Stems of Hibiscus taiwanensis

Pei-Lin Wu, Tian-Shung Wu, Cai-Xia He, Chia-Hao Su, Kuo-Hsiung Lee

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Keywords: Malvaceae, Hibiscus taiwanensis, lignan, triterpenoid, cytotoxicity, anti-HIV

JOURNAL FREE ACCESS

2005 Volume 53 Issue 1 Pages 56-59

DOI https://doi.org/10.1248/cpb.53.56

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Abstract

Five new compounds, hibicuslide A (1), hibicuslide B (2), hibicuslide C (3), hibicutaiwanin (4), hibicusin (5), and fifty-one known compounds have been isolated from the stems of Hibiscus taiwanensis. The structures of these compounds were determined by spectroscopic and chemical transformation methods. Among them, mansonone H (19) and uncarinic acid A (30) inhibited HIV replication in H9 lymphocyte cells. The 9,9′-O-feruloyl-(−)-secoisolaricinresinol (12), myriceric acid C (29), and uncarinic acid A (30) showed cytotoxic activity against human lung carcinoma and breast carcinoma.

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