Puerariafuran, a New Inhibitor of Advanced Glycation End Products (AGEs) Isolated from the Roots of Pueraria lobata

Dae Sik Jang; Jong Min Kim; Yun Mi Lee; Young Sook Kim; Joo-Hwan Kim; Jin Sook Kim

doi:10.1248/cpb.54.1315

Notes

Puerariafuran, a New Inhibitor of Advanced Glycation End Products (AGEs) Isolated from the Roots of Pueraria lobata

Dae Sik Jang, Jong Min Kim, Yun Mi Lee, Young Sook Kim, Joo-Hwan Kim, Jin Sook Kim

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Keywords: puerariafuran, coumestrol, advanced glycation end product (AGE), Pueraria lobata, Leguminosae

JOURNAL FREE ACCESS

2006 Volume 54 Issue 9 Pages 1315-1317

DOI https://doi.org/10.1248/cpb.54.1315

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Abstract

A new 2-arylbenzofuran, puerariafuran (1), as well as three known compounds, coumestrol (2), daidzein (3), and genistein (4), were isolated from a MeOH extract of the roots of Pueraria lobata as active constituents, using an in vitro bioassay based on the inhibition of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structure of 1 was determined by spectroscopic data interpretation, particularly by extensive 1D and 2D NMR studies. All the isolates (1—4) were evaluated for the inhibitory activity on AGEs formation in vitro.

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