Syntheses of Model Compounds Related to an Antigenic Epitope in Pectic Polysaccharides from Bupleurum falcatum L. (II)

Yuhua Jin; Noriyasu Hada; Junko Oka; Osamu Kanie; Shusaku Daikoku; Yoshimi Kanie; Haruki Yamada; Tadahiro Takeda

doi:10.1248/cpb.54.485

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Syntheses of Model Compounds Related to an Antigenic Epitope in Pectic Polysaccharides from Bupleurum falcatum L. (II)

Yuhua Jin, Noriyasu Hada, Junko Oka, Osamu Kanie, Shusaku Daikoku, Yoshimi Kanie, Haruki Yamada, Tadahiro Takeda

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Keywords: Bupleurum falcatum, glycocluster, glycodendrimer, β-alanine derivative, chemical synthesis

JOURNAL FREE ACCESS

2006 Volume 54 Issue 4 Pages 485-492

DOI https://doi.org/10.1248/cpb.54.485

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Abstract

Stereocontrolled syntheses of model compounds related to a major antigenic epitope against antibupleurum 2IIc/PG-1-IgG from antiulcer pectic polysaccharide are described. A trisaccharide derivative (13) was prepared as a precursor and a novel and simple approach for the rational design of a glycocluster and glycodendrimer was developed, through the syntheses of the fluorescence-labeled glycocluster (2) and glycodendrimer (3).

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