New Guaiane Sesquiterpenes from the Fruits of Torilis japonica

In-Kyoung Lee; Jeong-Hyung Lee; Eui Il Hwang; Bong-Sik Yun

doi:10.1248/cpb.56.1483

Notes

New Guaiane Sesquiterpenes from the Fruits of Torilis japonica

In-Kyoung Lee, Jeong-Hyung Lee, Eui Il Hwang, Bong-Sik Yun

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Keywords: Torilis japonica, Umbelliferae, nitric oxide production inhibitor, guaiane sesquiterpenoid

JOURNAL FREE ACCESS

2008 Volume 56 Issue 10 Pages 1483-1485

DOI https://doi.org/10.1248/cpb.56.1483

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Abstract

Three new guaiane type sesquiterpenes were isolated from the methanolic extract of the fruits of Torilis japonica together with a known compound, torilin (1). Their structures were established as 11-acetoxy-8-isobutyryl-4-guaien-3-one (2), 11-acetoxy-8-methacrylyl-4-guaien-3-one (3), and 11-acetoxy-8-propionyl-4-guaien-3-one (4) by spectroscopic methods. These compounds inhibited lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages RAW 264.7 cells.

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