Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Regular Articles
Diterpenes from Coleus forskohlii (WILLD.) BRIQ. (Labiatae)
Yupei ShanLingling XuYang LuXiaobing WangQitai ZhengLingyi KongMasatake Niwa
Author information
JOURNAL FREE ACCESS

2008 Volume 56 Issue 1 Pages 52-56

Details
Abstract

Three new minor labdane diterpene glycosides, forskoditerpenoside C, D, and E (1—3), and a novel labdane diterpene forskoditerpene A (4) were isolated from the ethanol extract of the whole plant of Coleus forskohlii. Their structures and relative stereochemistry were elucidated on the basis of extensive spectroscopic analyses including 1D-, 2D-NMR, and HR-ESI-MS experiments. Compounds 1—3 showed an unusual 8,13-epoxy-labd-14-en-11-one glycoside pattern. They showed relaxative effects on isolated guinea pig tracheal spirals in vitro. Compound 4 with a cyclopropyl, confirmed by a single-crystal X-ray diffraction determination, is the first known labdane derivative with a spiro element.

Content from these authors
© 2008 The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top