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Synthesis and Antiviral Activity Evaluation of some Novel Acyclic C-Nucleosides
2008 Volume 56 Issue 6 Pages 775-780
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2008 Volume 56 Issue 6 Pages 775-780
The preparation of novel 5-amino or 7-hydroxy substituted pyrazolo[4,3-b]pyridine and pyrazolo[3,4-c]pyridine acyclic C-nucleosides is described. Their synthesis was carried out by condensation of suitably substituted lithiated picolines with 2-benzyloxyethoxymethylchloride followed by pyrazole ring annulation. The compounds were evaluated for their antiviral activity against a wide panel of viruses, but were found inactive at subtoxic concentrations.
