A New Leishmanicidal Saponin from Brunfelsia grandiflora

Hiroyuki Fuchino; Setsuko Sekita; Kanami Mori; Nobuo Kawahara; Motoyoshi Satake; Fumiyuki Kiuchi

doi:10.1248/cpb.56.93

Notes

A New Leishmanicidal Saponin from Brunfelsia grandiflora

Hiroyuki Fuchino, Setsuko Sekita, Kanami Mori, Nobuo Kawahara, Motoyoshi Satake, Fumiyuki Kiuchi

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Keywords: Leishmania, Brunfelsia grandiflora, Solanaceae, chiricsanango, furostan

JOURNAL FREE ACCESS

2008 Volume 56 Issue 1 Pages 93-96

DOI https://doi.org/10.1248/cpb.56.93

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Abstract

A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O-β-D-glucopyranosyl 22α-methoxyfurost-3β,26-diol 3-O-β-D-xylopyranosyl(1→3)-{β-D-glucopyranosyl(1→2)}-β-D-glucopyranosyl(1→4)-β-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.

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