Synthesis, Antimicrobial and Antioxidant Activities of Sulfone Linked Bis Heterocycles—Pyrazolyl Oxadiazoles and Pyrazolyl Thiadiazole

Venkatapuram Padmavathi; Sanapalli Nagi Reddy; Konda Mahesh

doi:10.1248/cpb.57.1376

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Synthesis, Antimicrobial and Antioxidant Activities of Sulfone Linked Bis Heterocycles—Pyrazolyl Oxadiazoles and Pyrazolyl Thiadiazole

Venkatapuram Padmavathi, Sanapalli Nagi Reddy, Konda Mahesh

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Keywords: Z-styrylsulfonylacetic acid, pyrazolyl oxadiazole, pyrazolyl thiadiazole, antimicrobial activity, antioxidant property

JOURNAL FREE ACCESS

2009 Volume 57 Issue 12 Pages 1376-1380

DOI https://doi.org/10.1248/cpb.57.1376

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Abstract

A new class of bis heterocycles—sulfone linked pyrazolyl oxadiazoles and thiadiazoles were developed from Z-styrylsulfonylacetic acid. The pyrazolyl thiadiazoles exhibited excellent antimicrobial activity whereas pyrazolyl oxadiazoles displayed good antioxidant activity.

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