Synthesis and DNA Polymerase α and β Inhibitory Activity of Alkyl p-Coumarates and Related Compounds

Katsumi Nishimura; Yukiko Takenaka; Manami Kishi; Takao Tanahashi; Hiromi Yoshida; Chiaki Okuda; Yoshiyuki Mizushina

doi:10.1248/cpb.57.476

Regular Articles

Synthesis and DNA Polymerase α and β Inhibitory Activity of Alkyl p-Coumarates and Related Compounds

Katsumi Nishimura, Yukiko Takenaka, Manami Kishi, Takao Tanahashi, Hiromi Yoshida, Chiaki Okuda, Yoshiyuki Mizushina

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Keywords: alkyl p-coumarate ester, DNA polymerase, inhibitory activity

JOURNAL FREE ACCESS

2009 Volume 57 Issue 5 Pages 476-480

DOI https://doi.org/10.1248/cpb.57.476

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Abstract

trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases α and β. Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases α and β.

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