Synthesis and Configurational Stability of (S)- and (R)-Deuteriothalidomides

Takeshi Yamamoto; Etsuko Tokunaga; Shuichi Nakamura; Norio Shibata; Takeshi Toru

doi:10.1248/cpb.58.110

Notes

Synthesis and Configurational Stability of (S)- and (R)-Deuteriothalidomides

Takeshi Yamamoto, Etsuko Tokunaga, Shuichi Nakamura, Norio Shibata, Takeshi Toru

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Keywords: thalidomide, isostere, deuterium

JOURNAL FREE ACCESS

2010 Volume 58 Issue 1 Pages 110-112

DOI https://doi.org/10.1248/cpb.58.110

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Abstract

3′-Deuteriothalidomide was synthesized and found to be configurationally five times more stable than thalidomide toward racemization at physiological pH.

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