Constituents of Pongamia pinnata Isolated in a Screening for Activity to Overcome Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Resistance

Tomohiro Minakawa; Kazufumi Toume; Firoj Ahmed; Samir Kumar Sadhu; Takashi Ohtsuki; Midori A. Arai; Masami Ishibashi

doi:10.1248/cpb.58.1549

Notes

Constituents of Pongamia pinnata Isolated in a Screening for Activity to Overcome Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Resistance

Tomohiro Minakawa, Kazufumi Toume, Firoj Ahmed, Samir Kumar Sadhu, Takashi Ohtsuki, Midori A. Arai, Masami Ishibashi

Author information

Keywords: Pongamia pinnata, flavanone, screening

JOURNAL FREE ACCESS

2010 Volume 58 Issue 11 Pages 1549-1551

DOI https://doi.org/10.1248/cpb.58.1549

Details

Abstract

In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)-furanoflavanone (1), along with six known flavonoids (2—7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.

Corresponding author

Register with J-STAGE for free!