Anti-Hepatitis B Virus and Cytotoxic Diterpenoids from Isodon lophanthoides var. gerardianus

Li-bin Yang; Lin Li; Sheng-xiong Huang; Jian-xin Pu; Yong Zhao; Yun-bao Ma; Ji-jun Chen; Chun-hong Leng; Zheng-ming Tao; Han-dong Sun

doi:10.1248/cpb.59.1102

Regular Articles

Anti-Hepatitis B Virus and Cytotoxic Diterpenoids from Isodon lophanthoides var. gerardianus

Li-bin Yang, Lin Li, Sheng-xiong Huang, Jian-xin Pu, Yong Zhao, Yun-bao Ma, Ji-jun Chen, Chun-hong Leng, Zheng-ming Tao, Han-dong Sun

Author information

Li-bin Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Xi'an Medical University
Lin Li
Zhejiang Institution of Subtropical Crops
Sheng-xiong Huang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Jian-xin Pu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Yong Zhao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Yun-bao Ma
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Ji-jun Chen
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
Chun-hong Leng
Zhejiang Institution of Subtropical Crops
Zheng-ming Tao
Zhejiang Institution of Subtropical Crops
Han-dong Sun
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences

Keywords: Isodon lophanthoides var. gerardianus, diterpenoid, anti-hepatitis B virus

JOURNAL FREE ACCESS

2011 Volume 59 Issue 9 Pages 1102-1105

DOI https://doi.org/10.1248/cpb.59.1102

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Abstract

Four new diterpenoides, isolophanthins A—D (1—4) together with seven known abietane diterpenoides (5—11), have been isolated from Isodon lophanthoides var. gerardianus. The new diterpenoides were elucidated by spectroscopic analysis. Some of them showed significant activities against HBsAg and HBeAg of hepatitis B virus in Hep G 2.2.15 cells, as well as the human tumor cell lines, HL-60, A-549, MOLT-4, and BEL-7402.

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