Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Hyaluronidase Inhibitory Rosmarinic Acid Derivatives from Meehania urticifolia
Toshihiro Murata, Toshio Miyase, Fumihiko Yoshizaki
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Keywords: phenylpropanoid, rosmarinic acid, hyaluronidase inhibitor, Meehania urticifolia, Lamiaceae
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2011 Volume 59 Issue 1 Pages 88-95

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Abstract

Nine new phenylpropanoids, rashomonic acids A—D (1—4) and meehaniosides A—E (5—9), along with four known compounds were isolated from Meehania urticifolia. The structure of each new compound was elucidated based on the results of spectroscopic analyses. Compounds 3—8 showed moderate hyaluronidase inhibitory activity with IC50 values of 183—1049 μM.

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© 2011 The Pharmaceutical Society of Japan
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