Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
REVIEW
The Structure and Function of GGAs, the Traffic Controllers at the TGN Sorting Crossroads
Kazuhisa NakayamaSoichi Wakatsuki
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JOURNAL FREE ACCESS

2003 Volume 28 Issue 5 Pages 431-442

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Abstract

GGAs (Golgi-localizing, γ-adaptin ear homology domain, ARF-binding proteins) are a family of monomeric clathrin adaptor proteins that are conserved from yeasts to humans. Data published during the past four years have provided detailed pictures of the localization, domain organization and structure-function relationships of GGAs. GGAs possess four conserved functional domains, each of which interacts with cargo proteins including mannose 6-phosphate receptors, the small GTPase ARF, clathrin, or accessory proteins including Rabaptin-5 and γ-synergin. Together with or independent of the adaptor protein complex AP-1, GGAs regulate selective transport of cargo proteins, such as mannose 6-phosphate receptors, from the trans-Golgi network to endosomes mediated by clathrin-coated vesicles.

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© 2003 by Japan Society for Cell Biology
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