e-Journal of Surface Science and Nanotechnology
Online ISSN : 1348-0391
ISSN-L : 1348-0391
Conference -Nano-org. & Func.-
A Ribonucleopeptide Receptor Targets Phosphotyrosine
Tetsuya HasegawaKatsutoshi OhkuboSusumu YoshikawaTakashi Morii
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JOURNAL FREE ACCESS

2005 Volume 3 Pages 33-37

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Abstract

Tools for selective recognition and sensing of kinase-catalyzed phosphorylation at tyrosine or serine/threonine residues located on the protein surface are essential for understanding signal transduction cascades of living cell. A stable complex of RNA and peptide (ribonucleopeptide) provides a convenient approach to tailor a receptor for small molecules. In vitro selection of an RNA-derived pool of ribonucleopeptide afforded a ribonucleopeptide receptor specific for phosphotyrosine. The phosphotyrosine-binding ribonucleopeptide receptor discriminated phosphotyrosine against tyrosine, phosphoserine and phosphothreonine. [DOI: 10.1380/ejssnt.2005.33]

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この記事はクリエイティブ・コモンズ [表示 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by/4.0/deed.ja
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